HLA-DRB1*15 association with multiple sclerosis is confirmed in a multigenerational Italian family

A multigenerational family with multiple sclerosis.

We report a family with 15 individuals affected with multiple sclerosis present in three and possibly four generations. The segregation of multiple sclerosis within this pedigree is consistent with an autosomal dominant mode of inheritance with reduced penetrance. The clinical characteristics of the affected individuals are indistinguishable from those seen in sporadic multiple sclerosis with r...

Dietary Food Groups and Nutrient Intake in Association with Multiple Sclerosis: A Case-Control Study

Introduction: It has been proposed that dietary intake is associated with multiple sclerosis (MS). The present case-control study was conducted to investigate the relationship between intake of different food groups and occurrence of MS among the recently diagnosed adult patients in Yazd City, Iran. Materials and Methods: In the current study, a group of 45 patients who have recently been diag...

The Association Between Salt and Potassium Intake With Multiple Sclerosis

Background: The number of patients with Multiple Sclerosis (MS) is increasing in Iran. Studies have shown that high sodium chloride (salt) and low potassium intake are associated with the development of MS. High physiological salt concentrations can lead to the induction of Interleukin-17 (IL-17) accompanied by the excessive generation of helper T-17 cells (Th-17). This cytokine plays a critica...

Association of Apolipoprotein E Polymorphism with Susceptibility to Multiple Sclerosis

Perivenous demyelination: association with clinically defined acute disseminated encephalomyelitis and comparison with pathologically confirmed multiple sclerosis.

Distinction between acute disseminated encephalomyelitis and acute multiple sclerosis is often clinically difficult. Perivenous demyelination is the pathological hallmark of acute disseminated encephalomyelitis, whereas confluent demyelination is the hallmark of acute multiple sclerosis. We investigated whether perivenous demyelination versus confluent demyelination distinguishes acute dissemin...